The Saints will welcome the 49ers to the Mercedes-Benz Superdome on Sunday.
New Orleans has won five in a row, including a dominant blowout over the Buccaneers last weekend to get to 6-2.
The Saints are scoring the fourth-most points in the league while their defense is allowing the third-least yards per game.
San Francisco has been plagued with injuries this season and sits at 4-5 after two straight losses.
Nick Mullens will start again in place of Jimmy Garoppolo while Raheem Mostert remains out with a knee injury. Brandon Aiyuk will return after coming off the reserve/COVID-19 list.
Kickoff will be at 3:25 p.m. on FOX. 6,000 fans will be allowed inside the Superdome to cheer on the black and gold.
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