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The Saints have now lost four straight games.
New Orleans lost to the Tampa Bay Buccaneers 51-27 at the Caesars Superdome.
Spencer Rattler completed 22-of-40 passes for 243 yards, one touchdown and two interceptions in his first career start.
Alvin Kamara had 40 yards and a touchdown on the ground while Bub Means finished with five receptions for 45 yards and a TD.
The Saints are third in the NFC South at 2-4. They will host the Denver Broncos on Thursday Night Football in Week 7.
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