The Saints defense scored three times in a shootout as they sunk the Lions, 52-38, in New Orleans.
Kenny Vaccaro recovered a fumble in the end zone, while Cameron Jordan and Marshon Lattimore each recorded pick-sixes in the win. New Orleans forced five turnovers in the win.
Mark Ingram rumbled for 114 yards and two touchdowns, and Drew Brees tossed two scores for the 3-and-2 Saints.
The Lions scrapped back from a 45-10 deficit to make things interesting late, but the rally fell short. Matthew Stafford threw, three touchdowns, three interceptions and lost two fumbles for Detroit.
Defensive tackle A'Shawn Robinson returned an interception for a score, but the Lions dipped to 3-and-3.
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