LSU running back Derrius Guice rushed for 276 yards on 22 carries to lead the Tigers to victory in Oxford, Miss.
Guice holds the school record with 285 yards, achieved last year against Texas A&M. He is the first running back in SEC history to rush for more than 250 yards in at least three games.
It was a sweet win for LSU coach Ed Orgeron, who was the Rebels coach from 2005 to 2007.
LSU (6-2, 3-1 SEC) has won three consecutive games since losing its homecoming contest to Troy on Sept. 30.
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