Mark Ingram led a bruising Saints run game as they pounded the Bills, 47-10, in Buffalo.
Ingram finished with 131 rushing yards and three touchdowns for New Orleans. Alvin Kamara also eclipsed the 100-yard mark and rushed for a score. As a team, the Saints finished with 298 rushing yards, averaged more than six yards a carry, and ran for a team-record six touchdowns.
Michael Thomas caught nine passes for 117 yards as New Orleans won its seventh straight game.
The Bills could get nothing going offensively, and Tyrod Taylor was replaced by backup Nathan Peterman with the game out of hand in the fourth quarter. Peterman hooked up with Nick O'Leary on a seven-yard strike for Buffalo's only touchdown.
The Bills lost their first home game of the season, falling to 4-and-1 at New Era Field.
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