Antonio Blakeney, Bobby Portis and Zach LaVine scored 21 points apiece for Chicago. The trio combined to make 24 of 42 (57 percent) from the field and 14-of-14 free throws.
Jabari Parker, who signed with Chicago as a free agent in July, had 15 points but was just 5-of-14 shooting. Kris Dunn added 12 points and rookie Wendell Carter Jr. scored 11.
Frank Jackson and Jrue Holiday each scored 16 points for New Orleans. Jackson shot just 5 of 14 from the field but made 4-of-8 3-pointers. Holiday was 7-of-9 shooting with four assists.
Julius Randle, who signed with the Pelicans as a free agent this offseason, had 15 points, five rebounds and five assists. Anthony Davis added 13 points, three steals and two blocks in 15 minutes.
Nikola Mirotic (sore Achilles tendon) and Darius Miller (shoulder) did not play.
Jackson, a second-round pick out of Duke in 2017, missed all of last season due to a right foot injury.
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New Orleans (0-1) visits Atlanta on Monday.
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