DeMar DeRozan scored 26 points, LaMarcus Aldridge added 22 points and 12 rebounds and San Antonio extended New Orleans' losing streak to five games.
Dante Cunningham had a season-high 15 points, Patty Mills finished with 15 points, seven rebounds and seven assists and San Antonio won its fourth straight.
Jrue Holiday had 29 points and eight assists to lead the Pelicans. Nikola Mirotic posted 22 points and 16 rebounds. Anthony Davis had 17 points and eight rebounds after missing Thursday's game with a sprained right elbow.
Davis told reporters after the game the Pelicans are not doing their job on the defensive end. "We're not guarding anybody. We're making the game hard on ourselves. It shouldn't be this easy. It's hard to score buckets and then it's so easy for them on the other end. We're not physical, we're not stopping anybody one-on-one."
Pelicans head coach Alvin Gentry says they have to be smarter with the ball. "For every one you make, you make two or three turnovers and it ends up costing you. So what you want to be is, you want to be very conservative and move the basketball and you will get good shots."
New Orleans' road trip continues Monday night in Oklahoma City against the Thunder.
Information from the Associated Press contributed to this report.
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