Anthony Davis had 25 points and a season-high 20 rebounds, E'Twaun Moore scored a season-high 30 points and New Orleans snapped Toronto's six-game winning streak, 126-110.
Jrue Holiday had 29 points and matched a season high with 14 assists, and Julius Randle added 17 points and 12 rebounds as New Orleans won its third straight following a six-game losing streak.
The Pelicans outscored the Raptors 72-42 in the paint and snapped a six-game losing streak against Toronto.
Pascal Siakam scored 22 points, Kawhi Leonard had 20 and Serge Ibaka had 19 points and 14 rebounds as the Raptors lost for the first time in eight home games this season. Toronto entered with an NBA-best 12-1 record.
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