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The New Orleans Saints opened up the new season with a loss at home, falling to the Arizona Cardinals 20-13 at the Caesars Superdome.
Spencer Rattler completed 27-of-46 passes for 214 yards while falling to 0-7 as a starting quarterback.
Alvin Kamara rushed for 45 yards and a touchdown, while Juwan Johnson had eight receptions for 76 yards.
The Saints had their streak of six season-opening victories snapped and are now 0-1.
They will host the San Francisco 49ers on Sunday afternoon.
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